A Revolutionary Treatment to Restore Vessel Patency

The Alucent NVS Vessel Restoration System is designed to create a natural, stent-like scaffold using the body’s own tissue and processes. An all-in-one, integrated procedural system, Alucent NVS combines standard angioplasty techniques with a small molecule drug that when photoactivated, promotes extracellular matrix protein linking inside the vessel walls.

Designed to provide durable vessel patency, Alucent NVS has the potential to transform the way vascular disease is treated and improve long-term clinical outcomes in the treatment of many vascular diseases like Peripheral Artery Disease (PAD) and procedures such as creating durable ArterioVenous Fistulas (AVF) for dialysis patients.

Greater than 60% failure rate of balloon angioplasty after 12 months1

Studies show that balloon angioplasty and stenting have high failure rates and complications such as restenosis occur after only a year or two in patients with PAD. In contrast, Alucent NVS Technology is designed to provide durable vessel patency by creating a stent-like, natural scaffold in the vessel wall – eliminating the risk of complications specific to conventional stents and other implants. In preclinical studies, Alucent NVS has demonstrated the ability to expand the diameter of a blood vessel (artery or vein), without impacting the vessel’s native flexibility and function. Durable vessel patency provides a pathway to treat many vascular hurdles.

Currently Alucent is studying NVS Technology for the treatment of PAD and AVF. While these clinical trials are underway, Alucent has identified potential future application to explore, including Coronary Artery Disease, Carotid and renal artery intervention and preventing AAA progression.

1. Caradu, Caroline et al. Systematic review and updated meta-analysis of the use of drug-coated balloon angioplasty versus plain old balloon angioplasty for femoropopliteal arterial disease. Journal of Vascular Surgery. Volume 70, Issue 3, 981-995.e10.